Article
Mouse and rat strain variations in sensitivity to N-nitroso-diethylamine, hereditary transmission of the trait and the effect of 3-tert-butyl-4-hydroxyanisole on sensitivity.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology - 1 May 1992
Horie S, Ohbu M, Okudaira M
Abstract excerpt
1. Strain variations among male mice were studied in terms of the number of days of survival with chronic administration of N-nitroso-diethylamine (NDEA). Four inbred strains, two F1 progenies and one F2 progeny were tested. 2. BALB/c mice survived for the longest period, whereas C3H mice survive...
Topics
- Animals
- Anticarcinogenic Agents
- Butylated Hydroxyanisole
- Cytochrome P-450 Enzyme System
- Diethylnitrosamine
- Enzyme Induction
- Genetic Predisposition to Disease
- Liver
- Mice
- NAD(P)H Dehydrogenase (Quinone)
- Neoplasms, Experimental
- Phenobarbital
- Rats
- Species Specificity
- Survival Rate
- Time Factors