Article
Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 2015
Lubeck Beth A, Lapinski Philip E, Oliver Jennifer A, Ksionda Olga, Parada Luis F, Zhu Yuan, Maillard Ivan, Chiang Mark, Roose Jeroen, King Philip D
Abstract excerpt
Ras GTPase-activating proteins (RasGAPs) inhibit signal transduction initiated through the Ras small GTP-binding protein. However, which members of the RasGAP family act as negative regulators of T cell responses is not completely understood. In this study, we investigated potential roles for the RasGAPs RASA1 and neurofibromin 1 (NF1) in T cells through the generation and analysis of T cell-specific RASA1 and...
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