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Article

Galectin-3 regulates a molecular switch from N-Ras to K-Ras usage in human breast carcinoma cells.

Cancer research - 15 Aug 2005

Shalom-Feuerstein Ruby, Cooks Tomer, Raz Avraham, Kloog Yoel

Abstract excerpt

Galectin-3 (Gal-3), a pleiotropic carbohydrate-binding protein, is a selective binding partner of activated K-Ras-GTP. Because both proteins are antiapoptotic and associated with cancer progression, we questioned the possible functional role of Gal-3 in K-Ras activation. We found that overexpression of Gal-3 in human breast cancer cells (BT-549/Gal-3) coincided with a significant increase in wild-type (wt)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16103080
DOI: 10.1158/0008-5472.CAN-05-0775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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