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Human Papillomavirus Oncoprotein E6 Inactivates the Transcriptional Coactivator Human ADA3

28 Jul 2002

Abstract excerpt

High-risk human papillomaviruses (HPVs) are associated with carcinomas of the cervix and other genital tumors. The HPV oncoprotein E6 is essential for oncogenic transformation. We identify here hADA3, human homologue of the yeast transcriptional coactivator yADA3, as a novel E6-interacting protein and a target of E6-induced degradation. hADA3 binds selectively to the high-risk HPV E6 proteins and only to...

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PMID: 12138191
DOI: 10.1128/mcb.22.16.5801-5812.2002

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