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Article

WAVE3 Functions as a Negative Regulator of LDOC1

1 Nov 2005

Abstract excerpt

WAVE3 belongs to the Wiskott-Aldrich syndrome protein family that mediates actin reorganization through activation of the Arp2/3 complex. However, the physiological function of WAVE3 is poorly understood. We found that LDOC1-encoded by a gene that is down-regulated in tumor cell lines-binds directly to the verprolin homology domain of WAVE3. Ectopically expressed LDOC1 is localized in the nucleus and induces...

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Identifiers

PMID: 16272576
DOI: 10.1093/jb/mvi160

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