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p73β-Mediated Apoptosis Requires p57kip2 Induction and IEX-1 Inhibition

15 Mar 2005

Abstract excerpt

Similarly to p53, p73alpha and p73beta induce growth arrest and/or apoptosis in response to DNA damage or when exogenously expressed. However, how they trigger apoptosis remains unresolved. After stable transduction of either p73alpha or p73beta, a greater apoptotic response was observed for p73beta in both primary and tumor cells. Consistently, blocking ectopic and endogenous p73beta expression by specific shRNA...

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PMID: 15781630
DOI: 10.1158/0008-5472.can-04-3047

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