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Article

Cofilin-mediated Neuronal Apoptosis via p53 Translocation and PLD1 Regulation

11 Sept 2017

Abstract excerpt

Amyloid β (Aβ) accumulation is an early event in the pathogenesis of Alzheimer's disease (AD), leading to mitochondrial and synaptic dysfunction, tau accumulation, and eventual neuronal death. While the p53 apoptotic pathway has clearly been associated with Aβ deposits and neuronal apoptosis, the critical upstream factors contributing to p53 activation in AD are not well understood. We have previously shown that...

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PMID: 28912445
DOI: 10.1038/s41598-017-09996-3

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