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Article

Altered lung gene expression in CCSP-null mice suggests immunoregulatory roles for Clara cells.

American journal of physiology. Lung cellular and molecular physiology - 1 Dec 2001

Watson T M, Reynolds S D, Mango G W, Boe I M, Lund J, Stripp B R

Abstract excerpt

Clara cell secretory protein (CCSP) is one of the most abundant proteins present in airway lining fluid of mammals. In an effort to elucidate the function of CCSP, we established CCSP-null [CCSP(-/-)] mice and demonstrated altered sensitivity to various environmental agents including oxidant pollutants and microorganisms. Although CCSP deficiency itself may be central to the observed changes in environmental...

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Identifiers

PMID: 11704549
DOI: 10.1152/ajplung.2001.281.6.L1523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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