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Article

Attenuation of pulmonary neuroendocrine differentiation in mice lacking Clara cell secretory protein.

Laboratory investigation; a journal of technical methods and pathology - 1 Oct 2000

Castro C M, Yang Y, Zhang Z, Linnoila R I

Abstract excerpt

During development and injury, pulmonary neuroendocrine (NE) cells may transiently express Clara cell 10 kD protein (CC10), a major product of the nonciliated progenitor cells for normal and neoplastic airway epithelia suggesting a close relationship between the cells. To assess the role of CC10 during NE differentiation, we studied CC10-deficient mouse lungs by immunohistochemistry and digital imaging. The...

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PMID: 11045570
DOI: 10.1038/labinvest.3780163

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