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Article

Molecular Staging of Epithelial Maturation Using Secretory Cell–Specific Genes as Markers

28 Aug 2008

Abstract excerpt

Bronchiolar Clara cells undergo phenotypic changes during development and in disease. These changes are poorly described due to a paucity of molecular markers. We used chemical and transgenic approaches to ablate Clara cells, allowing identification of their unique gene expression profile. Flavin monooxygenase 3 (Fmo3), paraoxonase 1 (Pon1), aldehyde oxidase 3 (Aox3), and claudin 10 (Cldn10) were identified as...

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PMID: 18757308
DOI: 10.1165/rcmb.2007-0380oc

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