Article
Genetic variants of the tumour necrosis factor-alpha promoter gene do not influence the development of necrotizing enterocolitis.
Acta paediatrica (Oslo, Norway : 1992) - 1 Oct 2001
Treszl A, Kocsis I, Szathmári M, Schuler A, Tulassay T, Vásárhelyi B
Abstract excerpt
UNLABELLED: Previous studies indicated that elevated tumour necrosis factor-alpha (TNF-alpha) levels may play a role in the development of necrotizing enterocolitis (NEC). The A(-308) and A(-238) variants of the promoter region of the TNF-alpha gene are reportedly associated with altered TNF-alpha production. The aim of our study was to determine the impact of these gene polymorphisms on the development and...
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