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Article

Association of polymorphism within the promoter of the tumor necrosis factor alpha gene with increased risk of preterm premature rupture of the fetal membranes.

American journal of obstetrics and gynecology - 1 May 1999

Roberts A K, Monzon-Bordonaba F, Van Deerlin P G, Holder J, Macones G A, Morgan M A, Strauss J F, Parry S

Abstract excerpt

OBJECTIVE: The rarer allele of a polymorphism within the promoter region at position -308 of the gene for tumor necrosis factor alpha is associated with increased gene transcription. In this study we tested the hypothesis that this rarer allele is associated with spontaneous preterm birth. STUDY DESIGN: We conducted a case-control study of women admitted to our labor and delivery unit. To assess data from a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10329893
DOI: 10.1016/s0002-9378(99)70632-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of polymorphism within the promoter of the tumor necrosis factor alpha gene with increased risk of preterm premature rupture of the fetal membranes.PMID 10329893Read ↗

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A polymorphism in the promoter region of TNF and bacterial vaginosis: preliminary evidence of gene-environment interaction in the etiology of spontaneous preterm birth.Semantic proximity Read ↗

Adverse outcomes after preterm labor are associated with tumor necrosis factor-alpha polymorphism -863, but not -308, in mother-infant pairs.Semantic proximity Read ↗

Tumor necrosis factor-alpha gene G308A polymorphism is associated with the risk of preterm delivery.Semantic proximity Read ↗

Polymorphisms in the tumor necrosis factor alpha and interleukin 1-beta promoters with possible gene regulatory functions increase the risk of preterm birth.Semantic proximity Read ↗

A tumor necrosis factor-alpha promoter polymorphism and pregnancy complications: results of a prospective cohort study in 1652 pregnant women.Semantic proximity Read ↗

Polymorphisms in the tumor necrosis factor-alpha gene at position -308 and the inducible 70 kd heat shock protein gene at position +1267 in multifetal pregnancies and preterm premature rupture of fetal membranes.Semantic proximity Read ↗

Ethnic differences in key candidate genes for spontaneous preterm birth: TNF-alpha and its receptors.Semantic proximity Read ↗

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A promoter mutation that increases transcription of the tumor necrosis factor-alpha gene is not associated with preterm delivery.Semantic proximity Read ↗

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