Article
Evaluation of the associations between the single nucleotide polymorphisms of the promoter region of the tumor necrosis factor-alpha gene and nasopharyngeal carcinoma.
Journal of the Chinese Medical Association : JCMA - 1 Aug 2006
Ho Sheng-Yow, Wang Ying-Jan, Huang Po-Chang, Tsai Sen-Tien, Chen Chih-Hung, Chen Helen H W, Chang Chih-Jen, Guo How-Ran
Abstract excerpt
BACKGROUND: Tumor necrosis factor-alpha (TNF-alpha) is a pro-inflammatory cytokine and may act as an endogenous tumor promoter. Single nucleotide polymorphisms (SNPs) of the TNF-alpha gene promoter region have been found to be associated with certain cancers. We conducted a case-control study to evaluate the association between these SNPs and nasopharyngeal carcinoma (NPC). METHODS: We used polymerase chain...
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