Article
DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells.
The Journal of clinical investigation - 1 Nov 2001
Olaso E, Ikeda K, Eng F J, Xu L, Wang L H, Lin H C, Friedman S L
Abstract excerpt
Type I collagen provokes activation of hepatic stellate cells during liver injury through mechanisms that have been unclear. Here, we tested the role of the discoidin domain tyrosine kinase receptor 2 (DDR2), which signals in response to type I collagen, in this pathway. DDR2 mRNA and protein are induced in stellate cells activated by primary culture or in vivo during liver injury. The receptor becomes tyrosine...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.