Article
An update on complex I assembly: the assembly of players.
Journal of bioenergetics and biomembranes - 1 Aug 2014
Vartak Rasika S, Semwal Manpreet Kaur, Bai Yidong
Abstract excerpt
Defects in Complex I assembly is one of the emerging underlying causes of severe mitochondrial disorders. The assembly of Complex I has been difficult to understand due to its large size, dual genetic control and the number of proteins involved. Mutations in Complex I subunits as well as assembly factors have been reported to hinder its assembly and give rise to a range of mitochondria disorders. In this review,...
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