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Molecular mechanism of mitochondrial respiratory chain assembly and its relation to mitochondrial diseases.

Mitochondrion - 1 Jul 2020

Mukherjee Soumyajit, Ghosh Alok

Abstract excerpt

The mitochondrial respiratory chain (MRC) is comprised of ~92 nuclear and mitochondrial DNA-encoded protein subunits that are organized into five different multi-subunit respiratory complexes. These complexes produce 90% of the ATP required for cell sustenance. Specific sets of subunits are assembled in a modular or non-modular fashion to construct the MRC complexes. The complete assembly process is gradually...

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PMID: 32304865
DOI: 10.1016/j.mito.2020.04.002

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