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Article

HIV-1 Vpr protein activates the NF-κB pathway to promote G2/M cell cycle arrest.

Virologica Sinica - 1 Dec 2015

Liang Zhibin, Liu Ruikang, Lin Yongquan, Liang Chen, Tan Juan, Qiao Wentao

Abstract excerpt

Viral protein R (Vpr) plays an important role in the replication and pathogenesis of Human immunodeficiency virus type 1 (HIV-1). Some of the various functions attributed to Vpr, including the induction of G2/M cell cycle arrest, activating the NF-κB pathway, and promoting viral reverse transcription, might be interrelated. To test this hypothesis, a panel of Vpr mutants were investigated for their ability to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to vpr Gene Products, Human Immunodeficiency Virus

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Identifiers

PMID: 26676942
DOI: 10.1007/s12250-015-3654-8
PMCID: PMC8200914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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