Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 Vpr

1 Dec 1995

Abstract excerpt

Human immunodeficiency virus type 1 Vpr is a virion-associated, regulatory protein that is required for efficient viral replication in monocytes/macrophages. The protein is believed to act in conjunction with the Gag matrix protein to allow import of the viral preintegration complex in nondividing cells. In cells, Vpr localizes to the nucleus. Recently, we showed that Vpr prevents the activation of p34cdc2-cyclin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis B Virus Studies
Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7494303
DOI: 10.1128/jvi.69.12.7909-7916.1995

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of cell cycle arrest, nuclear localization and virion packaging of human immunodeficiency virus type 1 VprPMID 7494303Read ↗

Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 VprSemantic proximity Read ↗

The first HxRxG motif in simian immunodeficiency virus mac239 Vpr is crucial for G(2)/M cell cycle arrest.Semantic proximity Read ↗

Human immunodeficiency virus type 1 viral protein R (Vpr) arrests cells in the G2 phase of the cell cycle by inhibiting p34cdc2 activitySemantic proximity Read ↗

Effect of HIV-1 Vpr on Cell Cycle RegulatorsSemantic proximity Read ↗

HIV-1 Vpr: A Closer Look at the Multifunctional Protein from the Structural PerspectiveSemantic proximity Read ↗

Mutagenic analysis of human immunodeficiency virus type 1 Vpr: role of a predicted N-terminal alpha-helical structure in Vpr nuclear localization and virion incorporationSemantic proximity Read ↗

Mutational Analysis of Vpr-Induced G 2 Arrest, Nuclear Localization, and Cell Death in Fission YeastSemantic proximity Read ↗

Human immunodeficiency virus type 1 Vpr is a positive regulator of viral transcription and infectivity in primary human macrophages.Semantic proximity Read ↗

Exposed hydrophobic residues in human immunodeficiency virus type 1 Vpr helix-1 are important for cell cycle arrest and cell death.Semantic proximity Read ↗

Human immunodeficiency virus type 1 vpr protein transactivation function: mechanism and identification of domains involved.Semantic proximity Read ↗

The Role of Vpr in HIV-1 PathogenesisSemantic proximity Read ↗

Functional analysis of HIV-1 Vpr: identification of determinants essential for subcellular localization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.