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Article

Interleukin-10 and tumor necrosis factor gene polymorphisms and risk of coronary artery disease and myocardial infarction.

Atherosclerosis - 1 Nov 2001

Koch W, Kastrati A, Böttiger C, Mehilli J, von Beckerath N, Schömig A

Abstract excerpt

Inflammation plays an important role in the pathogenesis of atherosclerosis and acute coronary syndromes. Cytokines IL-10 and TNF-alpha exert opposite functions in inflammatory reactions, IL-10 acting predominantly as an antiinflammatory and TNF-alpha as a proinflammatory factor. Functional single nucleotide polymorphisms in the genes of IL-10, TNF-alpha, and TNF-beta are associated with gene expression and...

Topics

Coronary Disease
Female
Gene Frequency
Genotype
Humans
Interleukin-10
Linkage Disequilibrium
Lymphotoxin-alpha
Male
Middle Aged
Myocardial Infarction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Risk Factors

Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 11689215
DOI: 10.1016/s0021-9150(01)00467-1

Genes

TNF
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-11689215-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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