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Article

IL10 promoter variants are associated with gene expression but they are not markers of susceptibility to acute coronary syndrome.

Scientific reports - 8 Jun 2024

Garcia-Garduño Texali Candelaria, Padilla-Gutiérrez Jorge Ramón, Aceves-Ramírez Maricela, Parra-Reyna Brenda, Flores-Salinas Héctor Enrique, Valdes-Alvarado Emmanuel, Becerra-Loaiza Denisse Stephania, Quintero-Ramos Antonio, Roa-Bruzón Iliannis-Yisel, de la Cruz Andrea, Valle Yeminia

Abstract excerpt

Interleukin-10 (IL-10) is an immunomodulatory cytokine that plays a pivotal role in the pathogenesis of acute coronary syndromes (ACS). Here, we evaluated the role of IL10 promoter variants as markers for ACS susceptibility in Western Mexican patients as well as its association with IL10 mRNA and IL-10 plasma levels. Three promoter variants (- 1082 A > G, - 819 T > C and - 592 A > C) were analyzed in 300 ACS...

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Identifiers

PMID: 38851847
DOI: 10.1038/s41598-024-64097-2
PMCID: PMC11162414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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