Article
Gene polymorphisms in the TNF locus and the risk of myocardial infarction.
Thrombosis research - 15 Nov 2000
Padovani J C, Pazin-Filho A, Simões M V, Marin-Neto J A, Zago M A, Franco R F
Abstract excerpt
We investigated two genetic polymorphisms in the tumor necrosis factor locus (TNF-alpha -308 G-->A and LT-alpha +252 A-->G) as risk factors for coronary atherothrombotic disease (CAD) by determining its prevalence in 148 survivors of myocardial infarction (MI) with angiographically-proven severe CAD, and in 148 age-, gender- and race-matched controls. The odds ratio (OR) for MI related to the mutant TNF-alpha and...
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