Promoter variants of TNF-α rs1800629 and IL-10 rs1800871 are independently associated with the susceptibility of coronary artery disease in north Indian.

doi:10.1016/j.cyto.2018.04.035

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Article

Promoter variants of TNF-α rs1800629 and IL-10 rs1800871 are independently associated with the susceptibility of coronary artery disease in north Indian.

Cytokine - 1 Oct 2018

Kumari Reena, Kumar Sandeep, Ahmad Mohammad Kaleem, Singh Rajeev, Kant Kumar Shashi, Pradhan Akshayaya, Chandra Sharad, Kumar Sudhir

Abstract excerpt

BACKGROUND: Tumor necrosis factor-alpha (TNF-α) are considered as a pro inflammatory and interleukin-10 (IL-10) anti inflammatory have been shown to predict the risk of incident of coronary artery disease (CAD). The polymorphism at promoter of TNF-α and IL-10 has been shown to increase transcriptional activity of the gene and play a important role in patho physiology of CAD. Aim of present study is to examine the...

Topics

Alleles
Asian People
Biomarkers
Case-Control Studies
Coronary Artery Disease
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
India
Interleukin-10
Male

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Polymorphism, Single Nucleotide

Promoter Regions, Genetic

Tumor Necrosis Factor-alpha

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Open in PubMed

Identifiers

PMID: 29734056
DOI: 10.1016/j.cyto.2018.04.035

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