Article
Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development.
Development (Cambridge, England) - 1 Aug 2001
Nishinakamura R, Matsumoto Y, Nakao K, Nakamura K, Sato A, Copeland N G, Gilbert D J, Jenkins N A, Scully S, Lacey D L, Katsuki M, Asashima M, Yokota T
Abstract excerpt
SALL1 is a mammalian homolog of the Drosophila region-specific homeotic gene spalt (sal); heterozygous mutations in SALL1 in humans lead to Townes-Brocks syndrome. We have isolated a mouse homolog of SALL1 (Sall1) and found that mice deficient in Sall1 die in the perinatal period and that kidney agenesis or severe dysgenesis are present. Sall1 is expressed in the metanephric mesenchyme surrounding ureteric bud;...
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