Article
Sall1, sall2, and sall4 are required for neural tube closure in mice.
The American journal of pathology - 1 Nov 2008
Böhm Johann, Buck Anja, Borozdin Wiktor, Mannan Ashraf U, Matysiak-Scholze Uta, Adham Ibrahim, Schulz-Schaeffer Walter, Floss Thomas, Wurst Wolfgang, Kohlhase Jürgen, Barrionuevo Francisco
Abstract excerpt
Four homologs to the Drosophila homeotic gene spalt (sal) exist in both humans and mice (SALL1 to SALL4/Sall1 to Sall4, respectively). Mutations in both SALL1 and SALL4 result in the autosomal-dominant developmental disorders Townes-Brocks and Okihiro syndrome, respectively. In contrast, no human diseases have been associated with SALL2 to date, and Sall2-deficient mice have shown no apparent abnormal phenotype....
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