Article
Sall1, a causative gene for Townes-Brocks syndrome, enhances the canonical Wnt signaling by localizing to heterochromatin.
Biochemical and biophysical research communications - 18 Jun 2004
Sato Akira, Kishida Shosei, Tanaka Toshiya, Kikuchi Akira, Kodama Tatsuhiko, Asashima Makoto, Nishinakamura Ryuichi
Abstract excerpt
The Spalt (sal) gene family plays an important role in regulating developmental processes of many organisms. Mutations of human SALL1 cause the autosomal dominant disorder, Townes-Brocks syndrome (TBS), and result in ear, limb, anal, renal, and heart anomalies. Targeted deletion of mouse Sall1 results in kidney agenesis or severe dysgenesis. Molecular mechanisms of Sall1, however, have remained largely unknown....
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