Article
Rac1 regulates heat shock responses by reorganization of vimentin filaments: identification using MALDI-TOF MS.
Cell death and differentiation - 1 Nov 2001
Lee S Y, Song E J, Kim H J, Kang H J, Kim J H, Lee K J
Abstract excerpt
Rac1 has been implicated in a wide variety of biological processes, including actin remodeling and various signaling cascades. Here we have examined whether Rac1 might be involved in heat shock-induced cell signaling. We found that Rat2 stable cells expressing a dominant negative Rac1 mutant, RacN17 (Rat2-RacN17), were significantly more tolerant to heat shock than control Rat2 cells, and simultaneously inhibited...
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