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Article

Heterogeneous nuclear ribonucleoprotein K inhibits heat shock-induced transcriptional activity of heat shock factor 1.

The Journal of biological chemistry - 4 Aug 2017

Kim Hee-Jung, Lee Jae-Jin, Cho Jin-Hwan, Jeong Jaeho, Park A Young, Kang Wonmo, Lee Kong-Joo

Abstract excerpt

When cells are exposed to heat shock and various other stresses, heat shock factor 1 (HSF1) is activated, and the heat shock response (HSR) is elicited. To better understand the molecular regulation of the HSR, we used 2D-PAGE-based proteome analysis to screen for heat shock-induced post-translationally modified cellular proteins. Our analysis revealed that two protein spots typically present on 2D-PAGE gels and...

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Source

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Identifiers

PMID: 28592492
DOI: 10.1074/jbc.M117.774992
PMCID: PMC5546023

Genes

HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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