PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase.

doi:10.1038/370071a0

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Article

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase.

Nature - 7 Jul 1994

Chung J, Grammer T C, Lemon K P, Kazlauskas A, Blenis J

Abstract excerpt

Platelet-derived growth factor receptor (PDGF-R) phosphorylation at tyrosines 740/751 and insulin receptor phosphorylation of insulin receptor substrate-1 effects the recruitment and activation of phosphatidylinositol-3-OH kinase (PI(3)K). Changes in PI(3)K activity correlate with cell growth but...

Topics

3T3 Cells
Androstadienes
Animals
Cell Line
Enzyme Activation
Insulin
Mice
Mutation
Phosphatidylinositol 3-Kinases
Phosphotransferases (Alcohol Group Acceptor)
Platelet-Derived Growth Factor
Polyenes
Protein Kinase C
Protein Serine-Threonine Kinases
Receptor, Insulin
Receptors, Platelet-Derived Growth Factor
Ribosomal Protein S6 Kinases
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 8015612
DOI: 10.1038/370071a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8015612-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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