Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sp1 acts as a repressor of the human adenine nucleotide translocase-2 (ANT2) promoter.

European journal of biochemistry - 1 Nov 2001

Zaid A, Hodny Z, Li R, Nelson B D

Abstract excerpt

The human adenine nucleotide translocator-2 promoter is activated by adjacent Sp1 activation elements centered at nucleotides -79 and -68 (Abox and Bbox, respectively), and is repressed by Sp1 bound to a GC element (Cbox) that lies adjacent to transcription start. Here, we address the mechanism of this unique Sp1-mediated repression using transfected Drosophila SL2 and mammalian cell lines. We show that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cells, Cultured
Share to Mice
Share to Mitochondrial ADP, ATP Translocases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Promoter Regions, Genetic

Share to Regulatory Sequences, Nucleic Acid

Share to Repressor Proteins

Share to Sp1 Transcription Factor

Share to Transcription Initiation Site

Source

Identifiers

PMID: 11683873
DOI: 10.1046/j.1432-1033.2001.02453.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sp1 acts as a repressor of the human adenine nucleotide translocase-2 (ANT2) promoter.PMID 11683873Read ↗

AP-2 enhances Sp1-dependent activation of the growth-regulated human ATP/ADP translocator.Semantic proximity Read ↗

Promoter activity and distance constraints of one versus two Sp1 binding sites.Semantic proximity Read ↗

Sp1 and Sp3 transactivate the RET proto-oncogene promoter.Semantic proximity Read ↗

Sp1 is essential for both enhancer-mediated and basal activation of the TATA-less human adenosine deaminase promoter.Semantic proximity Read ↗

Lung surfactant protein B promoter function is dependent on the helical phasing, orientation and combinatorial actions of cis-DNA elements.Semantic proximity Read ↗

Multiple Sp1 sites efficiently drive transcription of the TATA-less promoter of the human glypican 3 (GPC3) gene.Semantic proximity Read ↗

Sp3 represses gene expression via the titration of promoter-specific transcription factors.Semantic proximity Read ↗

The E-box motif in the proximal ABCA1 promoter mediates transcriptional repression of the ABCA1 gene.Semantic proximity Read ↗

Characterization of the human ABO gene promoter in erythroid cell lineage.Semantic proximity Read ↗

Sp1 and chromatin environment are important contributors to the formation of repressive chromatin structures on the transfected human adenine nucleotide translocase-2 promoter.Semantic proximity Read ↗

O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions.Semantic proximity Read ↗

Regulation of mouse Ah receptor (Ahr) gene basal expression by members of the Sp family of transcription factors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.