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Article

Sp1 and Sp3 transactivate the RET proto-oncogene promoter.

Gene - 3 Oct 2000

Andrew S D, Delhanty P J, Mulligan L M, Robinson B G

Abstract excerpt

The RET proto-oncogene plays an important role in the initiation and progression of tumors derived from the neural crest. The cis-regulatory elements responsible for RET basal promoter activity have not been identified. To characterize these elements, a RET promoter DNA fragment (-453 to +227bp) was fused to a luciferase reporter and introduced into TT, a neural crest-derived cell line. Sequential 5' deletions of...

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Source

Identifiers

PMID: 11054558
DOI: 10.1016/s0378-1119(00)00302-4

Genes

RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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