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Article

AP-2 enhances Sp1-dependent activation of the growth-regulated human ATP/ADP translocator.

Journal of biochemistry - 1 Jul 1999

Li R, Hodny Z, Zaid A, Barath P, Nelson B D

Abstract excerpt

The mammalian ATP/ADP translocator isoform-2 (ANT2) gene is growth-activated. Regulation of the gene appears to involve Sp1, as an essential activator, and a suppressor through an Sp1 core element next to the transcription start. We show here that the proximal promoter also binds AP-2 strongly and specifically to two sites, one of which overlaps the Sp1 proximal suppressor site. AP-2 binds with an affinity of 10...

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Source

Identifiers

PMID: 10393330
DOI: 10.1093/oxfordjournals.jbchem.a022413

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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