Article
Association between COLIA1 Sp1 alleles and femoral neck geometry.
Calcified tissue international - 1 Aug 2001
Qureshi A M, McGuigan F E, Seymour D G, Hutchison J D, Reid D M, Ralston S H
Abstract excerpt
Genetic factors play an important role in the pathogenesis of osteoporosis by affecting bone mineral density and other predictors of osteoporotic fracture risk such as ultrasound properties of bone and skeletal geometry. We previously identified a polymorphism of a Sp1 binding site in the Collagen Type 1 Alpha 1 gene (COLIA1) that has been associated with reduced BMD and an increased risk of osteoporotic...
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