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Article

Relation of alleles of the collagen type Ialpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women.

The New England journal of medicine - 9 Apr 1998

Uitterlinden A G, Burger H, Huang Q, Yue F, McGuigan F E, Grant S F, Hofman A, van Leeuwen J P, Pols H A, Ralston S H

Abstract excerpt

BACKGROUND: Osteoporosis is a common disorder with a strong genetic component. One way in which the genetic component could be expressed is through polymorphism of COLIA1, the gene for collagen type Ialpha1, a bone-matrix protein. METHODS: We determined the COLIA1 genotypes SS, Ss, and ss in a po...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9535665
DOI: 10.1056/NEJM199804093381502

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-9535665-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Relation of alleles of the collagen type Ialpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women.PMID 9535665Read ↗

Polymorphism in the type I collagen (COLIA1) gene and risk of fractures in postmenopausal women.Semantic proximity Read ↗

Associations of the collagen type Ialpha1 Sp1 polymorphism with five-year rates of bone loss in older adults.Semantic proximity Read ↗

Prediction of osteoporotic fractures by bone densitometry and COLIA1 genotyping: a prospective, population-based study in men and women.Semantic proximity Read ↗

Collagen Ialpha1 Sp1 polymorphism, bone mass, and bone turnover in healthy French premenopausal women: the OFELY study.Semantic proximity Read ↗

An Sp1 Binding Site Polymorphism in the COLIA1 Gene Predicts Osteoporotic Fractures in Both Men and WomenSemantic proximity Read ↗

COLIA1 Sp1 polymorphism predicts response of femoral neck bone density to cyclical etidronate therapy.Semantic proximity Read ↗

Association of collagen type 1 alpha1 gene polymorphism with bone density in early childhood.Semantic proximity Read ↗

Contribution of the collagen I alpha1 and vitamin D receptor genes to the risk of hip fracture in elderly women.Semantic proximity Read ↗

COL1A1 Sp1 polymorphism predicts perimenopausal and early postmenopausal spinal bone loss.Semantic proximity Read ↗

Association of collagen type I alpha1 (COLIA1) Sp1 polymorphism with osteoporotic fracture in Caucasian post-menopausal women: a meta-analysis.Semantic proximity Read ↗

Association of polymorphism at the type I collagen (COL1A1) locus with reduced bone mineral density, increased fracture risk, and increased collagen turnoverSemantic proximity Read ↗

Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study.Semantic proximity Read ↗

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