Article
Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study.
PLoS medicine - 1 Apr 2006
Ralston Stuart H, Uitterlinden André G, Brandi Maria Luisa, Balcells Susana, Langdahl Bente L, Lips Paul, Lorenc Roman, Obermayer-Pietsch Barbara, Scollen Serena, Bustamante Mariona, Husted Lise Bjerre, Carey Alisoun H, Diez-Perez Adolfo, Dunning Alison M, Falchetti Alberto, Karczmarewicz Elzbieta, Kruk Marcin, van Leeuwen Johannes P T M, van Meurs Joyce B J, Mangion Jon, McGuigan Fiona E A, Mellibovsky Leonardo, del Monte Francesca, Pols Huibert A P, Reeve Jonathan, Reid David M, Renner Wilfried, Rivadeneira Fernando, van Schoor Natasja M, Sherlock Rachael E, Ioannidis John P A
Abstract excerpt
BACKGROUND: Osteoporosis and fracture risk are considered to be under genetic control. Extensive work is being performed to identify the exact genetic variants that determine this risk. Previous work has suggested that a G/T polymorphism affecting an Sp1 binding site in the COLIA1 gene is a genetic marker for low bone mineral density (BMD) and osteoporotic fracture, but there have been no very-large-scale studies...
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