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Article

COL1A1 Sp1 polymorphism predicts perimenopausal and early postmenopausal spinal bone loss.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 2001

MacDonald H M, McGuigan F A, New S A, Campbell M K, Golden M H, Ralston S H, Reid D M

Abstract excerpt

Genetic factors play an important role in the pathogenesis of osteoporosis but the genes that determine susceptibility to poor bone health are defined incompletely. Previous work has shown that a polymorphism that affects an Spl binding site in the COLIA1 gene is associated with reduced bone mineral density (BMD) and an increased risk of osteoporotic fracture in several populations. Data from cross-sectional...

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Source

Identifiers

PMID: 11547832
DOI: 10.1359/jbmr.2001.16.9.1634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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COL1A1 Sp1 polymorphism predicts perimenopausal and early postmenopausal spinal bone loss.PMID 11547832Read ↗

Associations of the collagen type Ialpha1 Sp1 polymorphism with five-year rates of bone loss in older adults.Semantic proximity Read ↗

Collagen Ialpha1 Sp1 polymorphism, bone mass, and bone turnover in healthy French premenopausal women: the OFELY study.Semantic proximity Read ↗

Prediction of osteoporotic fractures by bone densitometry and COLIA1 genotyping: a prospective, population-based study in men and women.Semantic proximity Read ↗

The Sp1 COLIA1 gene polymorphism, and not vitamin D receptor or estrogen receptor gene polymorphisms, determines bone mineral density in postmenopausal Greek women.Semantic proximity Read ↗

Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study.Semantic proximity Read ↗

COLIA1 Sp1 polymorphism predicts response of femoral neck bone density to cyclical etidronate therapy.Semantic proximity Read ↗

Polymorphism in the type I collagen (COLIA1) gene and risk of fractures in postmenopausal women.Semantic proximity Read ↗

An Sp1 Binding Site Polymorphism in the COLIA1 Gene Predicts Osteoporotic Fractures in Both Men and WomenSemantic proximity Read ↗

The Sp1 binding site polymorphism in the collagen type I alpha 1 (COLIA1) gene is not associated with bone mineral density in healthy children, adolescents, and young adults.Semantic proximity Read ↗

Relation of alleles of the collagen type Ialpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women.Semantic proximity Read ↗

Association of collagen type I alpha1 (COLIA1) Sp1 polymorphism with osteoporotic fracture in Caucasian post-menopausal women: a meta-analysis.Semantic proximity Read ↗

Effects of COLIA1 polymorphisms and haplotypes on perimenopausal bone mass, postmenopausal bone loss and fracture risk.Semantic proximity Read ↗

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