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Article

An Sp1 Binding Site Polymorphism in the COLIA1 Gene Predicts Osteoporotic Fractures in Both Men and Women

1 Sept 1998

Abstract excerpt

Genetic factors play an important role in the pathogenesis of osteoporosis, and recent studies have shown that a polymorphic Sp1 binding site in collagen type I alpha1 (COLIA1) gene is associated with bone mass and vertebral fractures in women from the U.K. Information on the predictive value of the COLIA1 Sp1 polymorphism in other populations is limited, however, and no studies have yet been performed in...

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PMID: 9738510
DOI: 10.1359/jbmr.1998.13.9.1384

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Related research

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Click a neighbor to travelStep 1 · 12 closest

An Sp1 Binding Site Polymorphism in the COLIA1 Gene Predicts Osteoporotic Fractures in Both Men and WomenPMID 9738510Read ↗

Prediction of osteoporotic fractures by bone densitometry and COLIA1 genotyping: a prospective, population-based study in men and women.Semantic proximity Read ↗

Polymorphism in the type I collagen (COLIA1) gene and risk of fractures in postmenopausal women.Semantic proximity Read ↗

Association of collagen type I alpha1 (COLIA1) Sp1 polymorphism with osteoporotic fracture in Caucasian post-menopausal women: a meta-analysis.Semantic proximity Read ↗

Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study.Semantic proximity Read ↗

Association of the collagen type 1 (COL1A 1) Sp1 binding site polymorphism to femoral neck bone mineral density and wrist fracture in 1044 elderly Swedish women.Semantic proximity Read ↗

Association of collagen type I alpha1 gene polymorphism with bone mineral density in osteoporotic women in Serbia.Semantic proximity Read ↗

Susceptibility to osteoporotic fracture is determined by allelic variation at the Sp1 site, rather than other polymorphic sites at the COL1A1 locus.Semantic proximity Read ↗

Interaction between the vitamin D receptor gene and collagen type Ialpha1 gene in susceptibility for fracture.Semantic proximity Read ↗

Collagen Ialpha1 Sp1 polymorphism, bone mass, and bone turnover in healthy French premenopausal women: the OFELY study.Semantic proximity Read ↗

Association between COLIA1 Sp1 alleles and femoral neck geometry.Semantic proximity Read ↗

Enhancement of absolute fracture risk prognosis with genetic marker: the collagen I alpha 1 gene.Semantic proximity Read ↗

Relation of alleles of the collagen type Ialpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women.Semantic proximity Read ↗

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