Article
Lack of Melanopsin Is Associated with Extreme Weight Loss in Mice upon Dietary Challenge.
PloS one - 1 Jan 2015
Aytürk Didem Göz, Castrucci Ana Maria, Carr David E, Keller Susanna R, Provencio Ignacio
Abstract excerpt
Metabolic disorders have been established as major risk factors for ocular complications and poor vision. However, little is known about the inverse possibility that ocular disease may cause metabolic dysfunction. To test this hypothesis, we assessed the metabolic consequences of a robust dietary challenge in several mouse models suffering from retinal mutations. To this end, mice null for melanopsin (Opn4-/-),...
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