Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant alleles of the Caenorhabditis elegans rde-1 gene identified through chemical mutagenesis of an snRNA misprocessing reporter.

G3 (Bethesda, Md.) - 9 Jul 2025

Waddell Brandon M, Wu Cheng-Wei

Abstract excerpt

The processing of small nuclear RNA post transcription involves endolytic cleavage of a 3' tail to produce a mature transcript that is incorporated into the spliceosome to regulate RNA splicing. We previously reported in the Caenorhabditis elegans model several novel genetic regulators including those functioning in RNAi processing to be required for snRNA cleavage through a genome-wide RNAi screen using an in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ethyl Methanesulfonate

Share to Genes, Reporter

Share to Mutagenesis

Share to RNA, Helminth

Share to RNA Interference

Share to RNA, Small Nuclear

Source

Open in PubMed Open full text

Identifiers

PMID: 40324366
DOI: 10.1093/g3journal/jkaf097
PMCID: PMC12239602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant alleles of the Caenorhabditis elegans rde-1 gene identified through chemical mutagenesis of an snRNA misprocessing reporter.PMID 40324366Read ↗

Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline.Semantic proximity Read ↗

Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi.Semantic proximity Read ↗

A role for the <i>C. elegans</i> Argonaute protein CSR-1b isoform in small nuclear RNA 3’ processingSemantic proximity Read ↗

Using RNA interference to identify specific modifiers of a temperature-sensitive, embryonic-lethal mutation in the Caenorhabditis elegans ubiquitin-like Nedd8 protein modification pathway E1-activating gene rfl-1.Semantic proximity Read ↗

A forward genetic screen in C. elegans identifies conserved residues of spliceosomal proteins PRP8 and SNRNP200/BRR2 with a role in maintaining 5' splice site identity.Semantic proximity Read ↗

Nuclear Argonaute HRDE-1 Maintains Chromatin-Independent Transcriptional Silencing through a Transgenerational Small RNA Feedback LoopSemantic proximity Read ↗

The near demise and subsequent revival of classical genetics for investigating Caenorhabditis elegans embryogenesis: RNAi meets next-generation DNA sequencing.Semantic proximity Read ↗

Distinct roles for RDE-1 and RDE-4 during RNA interference in Caenorhabditis elegans.Semantic proximity Read ↗

The rde-1 gene, RNA interference, and transposon silencing in C. elegans.Semantic proximity Read ↗

Rapid and Efficient Identification of Caenorhabditis elegans Legacy Mutations Using Hawaiian SNP-Based Mapping and Whole-Genome Sequencing.Semantic proximity Read ↗

Distinct phases of siRNA synthesis in an endogenous RNAi pathway in C. elegans soma.Semantic proximity Read ↗

Engineering of a conditional allele reveals multiple roles of XRN2 in Caenorhabditis elegans development and substrate specificity in microRNA turnover.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.