Article
Genetic polymorphism of cytochrome P450 2C9 in a Caucasian and a black African population.
British journal of clinical pharmacology - 1 Oct 2001
Scordo M G, Aklillu E, Yasar U, Dahl M L, Spina E, Ingelman-Sundberg M
Abstract excerpt
AIMS: CYP2C9 is a major enzyme in human drug metabolism and the polymorphism observed in the corresponding gene may affect the therapeutic outcome during treatment with several drugs. The distribution of variant CYP2C9 alleles was therefore investigated in an Italian and an Ethiopian population. METHODS: Allele-specific PCR analysis was carried out in order to determine the frequencies of the two most common...
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