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Amplification of the androgen receptor may not explain the development of androgen‐independent prostate cancer

1 Oct 2001

Abstract excerpt

OBJECTIVE: To examine the role of androgen receptor (AR) gene amplification and aneusomy of the X chromosome in the development of antiandrogen-resistant prostate cancer. PATIENTS AND METHODS: Twenty patients with prostate cancer resistant to androgen-deprivation therapy were selected for study. The records of patients with tumours before and after antiandrogen therapy, and with a full clinical follow-up, were...

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PMID: 11678763
DOI: 10.1046/j.1464-410x.2001.02350.x

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