Article
Gene amplification and mutation analysis of epidermal growth factor receptor in hormone refractory prostate cancer.
The Prostate - 1 Jun 2008
Cho Kang Su, Lee Joong Shik, Cho Nam Hoon, Park Kyeongmee, Ham Won Sik, Choi Young Deuk
Abstract excerpt
BACKGROUND: Amplification and mutation of the epidermal growth factor receptor (EGFR) and Her-2 genes were analyzed in both hormone sensitive and hormone refractory prostate cancer (HRPC). METHODS: Gene amplifications of EGFR and Her-2 were analyzed by fluorescence in situ hybridization (FISH) with direct sequencing. Studies were performed on a total of 10 patients; tissues were sampled at the time of initial...
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