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Androgen receptor gene amplification increases tissue PSA protein expression in hormone-refractory prostate carcinoma

1 Oct 1999

Abstract excerpt

Androgen receptor (AR) gene amplification was analysed by fluorescence in situ hybridization (FISH) from 24 paraffin-embedded prostate carcinoma samples recurring locally during hormonal therapy and prostate-specific antigen (PSA) expression from 15/24 of these samples was studied by immunohistochemistry (IHC). AR gene amplification was detected in 29 per cent (7/24) of the recurrent tumours. Using modified...

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PMID: 10547578
DOI: 10.1002/(sici)1096-9896(199910)189:2<219::aid-path423>3.0.co;2-f

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