Article
Additional activation of the AR gene may be involved in the development of the castration resistance phenotype in prostate cancer.
Actas urologicas espanolas - 1 Mar 2022
Romão P, Souza Í de Campos, Silva I, Guimarães V R, Camargo J Alves de, Dos Santos G A, Viana N I, Srougi M, Leite K R Moreira, Reis S T, Pimenta R
Abstract excerpt
INTRODUCTION: Several studies have already shown that changes in the AR gene may be associated with a more aggressive disease phenotype and even castration-resistant prostate cancer. Thus, we investigated cytogenetic and molecular alterations linked to AR. MATERIALS AND METHODS: To evaluate AR methylation, we performed a cytogenetic-molecular analysis using fluorescence in situ hybridization that uses specific...
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