Isotype-switched immunoglobulin genes with a high load of somatic hypermutation and lack of ongoing mutational activity are prevalent in mediastinal B-cell lymphoma.

doi:10.1182/blood.v98.9.2762

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Article

Isotype-switched immunoglobulin genes with a high load of somatic hypermutation and lack of ongoing mutational activity are prevalent in mediastinal B-cell lymphoma.

Blood - 1 Nov 2001

Leithäuser F, Bäuerle M, Huynh M Q, Möller P

Abstract excerpt

Primary mediastinal B-cell lymphoma (PMBL) is a subentity of diffuse large B-cell lymphoma with characteristic clinical, histomorphologic, immunophenotypical, and genetic features. Unlike other B-cell lymphomas, PMBL has not yet been the subject of comprehensive molecular studies on the rearranged immunoglobulin (Ig) gene. Such investigations have proved essential to obtaining information about the...

Topics

Adult
Antibodies, Neoplasm
Base Sequence
Clone Cells
Female
Gene Expression Regulation
Gene Rearrangement
Humans
Immunoglobulin Class Switching
Immunoglobulin G
Immunoglobulin Heavy Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Variable Region

Lymphoma, B-Cell

Lymphoma, Large B-Cell, Diffuse

Male

Mediastinal Neoplasms

Middle Aged

Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 11675349
DOI: 10.1182/blood.v98.9.2762

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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