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Article

Isotype-switched immunoglobulin genes with a high load of somatic hypermutation and lack of ongoing mutational activity are prevalent in mediastinal B-cell lymphoma.

Blood - 1 Nov 2001

Leithäuser F, Bäuerle M, Huynh M Q, Möller P

Abstract excerpt

Primary mediastinal B-cell lymphoma (PMBL) is a subentity of diffuse large B-cell lymphoma with characteristic clinical, histomorphologic, immunophenotypical, and genetic features. Unlike other B-cell lymphomas, PMBL has not yet been the subject of comprehensive molecular studies on the rearranged immunoglobulin (Ig) gene. Such investigations have proved essential to obtaining information about the...

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Share to Antibodies, Neoplasm
Share to Immunoglobulin Class Switching

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoglobulin Variable Region

Share to Lymphoma, B-Cell

Share to Lymphoma, Large B-Cell, Diffuse

Share to Mediastinal Neoplasms

Share to RNA, Neoplasm

Share to Somatic Hypermutation, Immunoglobulin

Source

Identifiers

PMID: 11675349
DOI: 10.1182/blood.v98.9.2762

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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