Article
Clinical relevance of immunoglobulin mutation analysis.
Current opinion in oncology - 1 Sept 2000
Hummel M, Stein H
Abstract excerpt
The precise diagnosis of malignant B-cell lymphoproliferations is essential for their appropriate clinical management. Histologic and immunophenotypical features alone are often insufficient in discriminating between various lymphoma entities and subtypes. The analysis of clonally rearranged immunoglobulin chain genes of the tumor cells was therefore suggested as an additional parameter. This article reviews...
Topics
- B-Lymphocytes
- Clone Cells
- DNA Mutational Analysis
- Gene Rearrangement
- Genes, Immunoglobulin
- Humans
- Immunoglobulin Heavy Chains
- Immunoglobulin Light Chains
- Lymphoma, B-Cell
- Mutation