Conserved as well as divergent regulatory elements account for expression of the human and rodent phenylalanine hydroxylase genes.

doi:10.1016/s0378-1119(01)00630-8

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Article

Conserved as well as divergent regulatory elements account for expression of the human and rodent phenylalanine hydroxylase genes.

Gene - 22 Aug 2001

Bristeau A, Catherin A, Weiss M C, Faust D M

Abstract excerpt

We have uncovered a fundamental difference in the regulation of the rodent and the human phenylalanine hydroxylase (PAH) genes: expression of human PAH is independent of glucocorticoids and/or cAMP in contrast to the mouse gene which is not only highly inducible but dependent upon hormones for expression. Nevertheless, the two genes do exhibit similarities: DNaseI hypersensitive sites are identically located in...

Topics

Animals
Binding Sites
Binding, Competitive
Chloramphenicol O-Acetyltransferase
Conserved Sequence
Cyclic AMP
DNA
DNA-Binding Proteins
Deoxyribonuclease I
Dexamethasone
Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Enzymologic

Genetic Variation

Hepatocyte Nuclear Factor 1

Hepatocyte Nuclear Factor 1-alpha

Hepatocyte Nuclear Factor 1-beta

Hormones

Humans

Source

Open in PubMed

Identifiers

PMID: 11675021
DOI: 10.1016/s0378-1119(01)00630-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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