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Article

Epigenetic reactivation of transcriptional programs orchestrating fetal lung development in human pulmonary hypertension

8 Jun 2022

Abstract excerpt

Phenotypic alterations in resident vascular cells contribute to the vascular remodeling process in diseases such as pulmonary (arterial) hypertension [P(A)H]. How the molecular interplay between transcriptional coactivators, transcription factors (TFs), and chromatin state alterations facilitate the maintenance of persistently activated cellular phenotypes that consequently aggravate vascular remodeling processes...

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PMID: 35675437
DOI: 10.1126/scitranslmed.abe5407

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