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Article

Human ovarian surface epithelial cells immortalized with hTERT maintain functional pRb and p53 expression

14 Sept 2007

Abstract excerpt

OBJECTIVE: Cell immortalization is considered to be a prerequisite status for carcinogenesis. Normal human ovarian surface epithelial (OSE) cells, which are thought to be the origin of most of human ovarian carcinomas, have a very limited lifespan in culture. Establishment of immortalized OSE cell lines has, in the past, required inactivation of pRb and p53 functions. However, this often leads to increased...

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PMID: 17877616
DOI: 10.1111/j.1365-2184.2007.00462.x

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