Article
Epithelio-mesenchymal transition in a neoplastic ovarian epithelial hybrid cell line.
Differentiation; research in biological diversity - 1 Apr 2004
Maines-Bandiera Sarah L, Huntsman David, Lestou Valia S, Kuo Wen-Lin, Leung Peter C K, Horsman R Douglas, Wong Alice S T, Woo Michelle M M, Choi Keith K C, Roskelley Calvin D, Auersperg Nelly
Abstract excerpt
A hybrid cell line, IOSE-Ov29, was created through fusion of cells from the human ovarian adenocarcinoma line OVCAR3 and the non-tumorigenic SV40 Tag-transfected human ovarian surface epithelial line IOSE-29. OVCAR3 cells exhibit a differentiated epithelial phenotype, whereas line IOSE-29 expresses mesenchymal characteristics that were acquired in culture by epithelio-mesenchymal transition. Microsatellite...
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