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Article

Interferon-gamma regulates susceptibility to collagen-induced arthritis through suppression of interleukin-17.

Arthritis and rheumatism - 1 Apr 2007

Chu Cong-Qiu, Swart David, Alcorn Dina, Tocker Joel, Elkon Keith B

Abstract excerpt

OBJECTIVE: The enhanced expression of experimental arthritis in the absence of interferon-gamma (IFNgamma) suggests that IFNgamma suppresses arthritis. Interleukin-17 (IL-17) is a pivotal T cell cytokine in arthritis, and in vitro studies have indicated that IFNgamma suppresses IL-17 production. We undertook this study to test the hypothesis that resistance to collagen-induced arthritis (CIA) in C57BL/6 (B6) mice...

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Identifiers

PMID: 17393396
DOI: 10.1002/art.22453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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